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5 Facts you should know about

Charcot-Marie-Tooth disease



Charcot-Marie-Tooth disease is a group of disorders that affect the peripheral nerves, the nerves running from outside the brain and spine


The Charcot-Marie-Tooth disease (CMT) is named after the 3 physicians who first described it: Drs. Jean-Martin Charcot and Pierre Marie (both from France) and Howard Henry Tooth (of the United Kingdom)


There are over 40 types of Charcot-Marie-Tooth disease


Common symptoms may include

foot drop, foot deformity, loss of lower leg muscle, numbness in the foot or leg, “slapping" gait (feet hit the floor hard when walking), and weakness of the hips, legs, or feet.


There are over 100 different gene mutations associated with causing CMT. Most people (90%) have 1 of 4 types of CMT: CMT 1A (PMP 22), CMT 1B (MPZ), CMT 2A (MFN2), and CMT 1X (GJB1)

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