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Disease Profile
Burkitt lymphoma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Burkitt's lymphoma; BL
Categories
Blood Diseases; Rare Cancers
Summary
Burkitt lymphoma (BL) is a very fast-growing type of
- Endemic (African) the most common form, found mainly in central Africa, where it is associated with the Epstein Barr virus (EBV).[2] It is most common in children. This form often manifests as enlargement of the jaw or facial bones.[3]
- Sporadic a rarer form, seen in all parts of the world, that often develops in the abdomen with bone marrow involvement. The kidneys, ovaries, breasts or other
organs may also be involved.[3][2] This form commonly affects children and young adults.[4] Immunodeficiency -associated occurs primarily in people with HIV infection, and less commonly in people with other immunodeficiency disorders or recipients of organ transplants.[2][5]
Signs and symptoms may differ depending on the form of BL and the organs or body systems involved.[2] When it spreads, weakness and fatigue often develop. Lymphoma cells may build up in the
The exact cause of BL is not known. EBV infection appears to play a role in virtually all cases of endemic (African) BL, and a minority of sporadic and immunodeficiency-associated BL.[5] While acquired (not
Without timely treatment, BL is rapidly fatal. Treatment involves intensive
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names |
Learn More:
HPO ID
|
|---|---|---|
| 30%-79% of people have these symptoms | ||
| Abnormality of bone marrow |
0005561 | |
| Hyperuricemia |
High blood uric acid level
|
0002149 |
| Increased lactate dehydrogenase level | 0025435 | |
| 0100649 | ||
| 5%-29% of people have these symptoms | ||
| Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
| Abnormality of the liver |
Abnormal liver
Liver abnormality
[ more ] |
0001392 |
| Abnormality of the |
Abnormal lymph node histology
|
0002733 |
| Abnormality of the ovary |
Abnormality of the ovaries
|
0000137 |
| Abnormality of the pancreas | 0001732 | |
| Abnormality of the spleen | 0001743 | |
| Decreased proportion of CD4-positive helper T cells | 0005407 | |
| Gastrointestinal hemorrhage |
Gastrointestinal bleeding
|
0002239 |
| Intestinal obstruction |
Bowel obstruction
Intestinal blockage
[ more ] |
0005214 |
| Nausea and vomiting | 0002017 | |
| Percent of people who have these symptoms is not available through HPO | ||
| Burkitt lymphoma | 0030080 | |
|
Decreased immune function
|
0002721 | |
| 0001428 | ||
| Sporadic |
No previous family history
|
0003745 |
Diagnosis
Making a diagnosis for a genetic or rare disease can often be challenging. Healthcare professionals typically look at a person’s medical history, symptoms, physical exam, and laboratory test results in order to make a diagnosis. The following resources provide information relating to diagnosis and testing for this condition. If you have questions about getting a diagnosis, you should contact a healthcare professional.
Testing Resources
- The Genetic Testing Registry (GTR) provides information about the genetic tests for this condition. The intended audience for the GTR is health care providers and researchers. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
|
Conditions with similar signs and symptoms from Orphanet
|
|---|
|
Differential diagnoses include other forms of abdominal tumors in children (Wilms tumor and neuroblastomas, although these are retroperitoneal, and desmoplastic tumors; see these terms) and other types of lymphoma and leukemia of B and T precursors in cases with bone marrow involvement.
Visit the Orphanet disease page for more information.
|
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
Leukemia and Lymphoma Society
3 International Drive, Suite 200
Rye Brook, NY 10573
Toll-free: 1-(800) 955-4572 (patients and families)
Telephone: 1-(888) 557-7177 (general)
E-mail: https://www.lls.org/content/contact-us
Website: https://www.lls.org/ -
Lymphoma Research Foundation
Wall Street Plaza
88 Pine Street, Suite 2400
New York, NY 10005
Toll-free: 1-800-500-9976
Telephone: +1-212-349-2910
Fax: +1-212-349-2886
E-mail: [email protected]
Website: https://www.lymphoma.org/
Social Networking Websites
- Visit the following Facebook groups related to Burkitt lymphoma:
Burkitt's Lymphoma Society Private Group
Burkitt's Lymphoma Support Group
Burkitt's Lymphoma Society
Organizations Providing General Support
-
American Cancer Society
250 Williams Street NW
Atlanta, GA 30329
Toll-free: 1-800-227-2345
Website: https://www.cancer.org
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Merck Manual for health care professionals provides information on Burkitt lymphoma.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Burkitt lymphoma. Click on the link to view a sample search on this topic.
References
- Portlock CS. Burkitt Lymphoma. Merck Manual Consumer Version. https://www.merckmanuals.com/home/blood-disorders/lymphomas/burkitt-lymphoma. Accessed 9/25/2017.
- Kanbar AH. Burkitt Lymphoma and Burkitt-like Lymphoma. Medscape Reference. April 8, 2016; https://emedicine.medscape.com/article/1447602-overview.
- Portlock CS. Burkitt Lymphoma. Merck Manual Professional Version. October, 2012; https://www.merckmanuals.com/professional/hematology-and-oncology/lymphomas/burkitt-lymphoma.
- Dunleavy K, Little RF, Wilson WH. Update on Burkitt Lymphoma. Hematol Oncol Clin North Am. December, 2016; 30(6):1333-1343. https://www.ncbi.nlm.nih.gov/pubmed/27888884.
- Freedman AS, Aster JC. Epidemiology, clinical manifestations, pathologic features, and diagnosis of Burkitt lymphoma. UpToDate. Waltham, MA: UpToDate; August, 2017; https://www.uptodate.com/contents/epidemiology-clinical-manifestations-pathologic-features-and-diagnosis-of-burkitt-lymphoma.
- Hamosh A. Burkitt lymphoma; BL. OMIM. July 6, 2017; https://omim.org/entry/113970.
- Freedman AS, Friedberg JW. Treatment of Burkitt leukemia/lymphoma in adults. UpToDate. Waltham, MA: UpToDate; August, 2017; https://www.uptodate.com/contents/treatment-of-burkitt-leukemia-lymphoma-in-adults.
- Casulo C, Friedberg J. Treating Burkitt Lymphoma in Adults. Curr Hematol Malig Rep. September, 2015; 10(3):266-271. https://link.springer.com/article/10.1007/s11899-015-0263-4.
- Burkitt lymphoma. MedlinePlus. May 20, 2016; https://medlineplus.gov/ency/article/001308.htm.
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