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5 Facts you should know about

Autoimmune autonomic ganglionopathy (AAG)

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1

AAG is an acquired immune-mediated disorder that leads to systemic autonomic failure

2

Symptoms may include severe orthostatic hypotension, fainting, constipation, fixed and dilated pupils, urinary retention, and dry mouth and eyes

3

In idiopathic AAG, the body's own immune system targets a receptor in the autonomic ganglia, which is part of a peripheral nerve fiber

4

If the AAG is paraneoplastic, there is a form of cancer, and the immune system has produced paraneoplastic antibodies in response to the cancer

5

Approximately one-third of people with AAG get better without treatment, but the recovery is often incomplete

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